The Brain and Music

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Pseudotumor cerebri: how can music make a difference?

January 10th, 2010 · music and the brain

Recently a friend of mine was given this diagnosis:  Pseudotumor cerebri.  She had been having terrible headaches and was experiencing increasingly blurry vision.  Today she had an MRI and a spinal tap.  Unfortunately, the spinal tap did not get any fluid so she has to have one done again on Monday.  The first thing I asked myself was whether or not music might be able to help.  Now hopefully on Monday she will at least take her iPod with her and have queued up some music that will distract her from the procedure.

There are many medical procedures that can be greatly eased simply by listening to music through headphones or on an iPod.  Think about this when you’re told that you need a certain procedure and if possible, plan the music that you want to listen to very specifically in advance.  I can program headphones for you, but you can also do it for yourself if you have time.
Papilledema is defined as disc swelling produced by increased ICP; it may be asymmetric, UL, or BL. True optic disc swelling or edema can be a very ominous sign.  Acutely, the vision, color vision, and pupillary responses are normal, but the blind spot is increased on visual field testing. Chronic forms lead to loss of vision and loss of visual fields. Fortunately, most perceived optic disc swelling is a manifestation of a congenital optic disc variation.

Differential Diagnosis

Pseudotumor cerebri

–Other symptoms: Headache, nausea, and vomiting all worse in morning, transient visual obscurations, diplopia

–Diagnosis includes increased ICP, normal imaging, normal CSF

–More common in obese females

Optic neuritis

–May be associated with postviral syndromes or meningoencephalitis

–Loss of vision, pain on eye movement

–Vision usually improves within a few weeks, but not full recovery

Optic neuropathy

–Compressive: Associated with NF1 and optic nerve glioma, presents with progressive visual loss, strabismus, nystagmus, proptosis

–Infiltrative: From cancers (leukemias, lymphomas), infection, or inflammation (sarcoidosis, TB, toxocariasis, toxoplasmosis, CMV); optic disc swelling, vision loss, and hemorrhages

–Toxic/nutritional optic neuropathy: Symmetric neuropathy from nutritional deficiency (thiamine, B12), drugs (tobacco/alcohol, chloramphenicol, rifampin), toxins (lead, methanol); visual field and vision loss; may recover with treatment

–Leber optic neuropathy: Mitochondrial DNA transmission, presents late teens to middle 20s; visual field and vision loss, may spontaneously improve

Increased ICP: Idiopathic intracranial hypertension, intracranial hemorrhage, space-occupying lesion

Growth hormone supplementation

Retinal hemorrhage and loss of vision

Retinal vein occlusion

Malignant hypertension: Associated with retinal hemorrhage, exudates, and cotton wool spots

Optic neuropathy, nonarteritic or arteritic

Demyelinating disease

Infectious conditions: Toxoplasmosis, Lyme disease, Bartonella; hard exudates may be visible funduscopically

Workup and Diagnosis

History

–History of HA, nausea or vomiting, recent viral illness

–Family history of visual loss, neurologic disorder

–PMH or signs and symptoms consistent with known systemic diseases; e.g., hypertension, diabetes, thyroid disease, growth hormone therapy

–Nutritional deficiencies; exposure to toxins such as tobacco or alcohol; recent drug use; exposure to ticks and animals

Physical exam

–Visual acuity, confrontational visual fields, pupillary response, extraocular muscle movements, proptosis

–Dilated fundus evaluation

–Neurologic exam for signs and symptoms of demyelinating disease, localizing deficit

Labs

–Titers for CMV, Lyme, toxocariasis, toxoplasmosis

Radiology

–CT or MRI of the brain and orbits for suspicion of intracranial mass, mass effect or hemorrhage

Studies

–Lumbar puncture may be indicated to establish presence or absence of, or to relieve, increased intracranial pressure

Ophthalmologic consultation to rule out congenital variation to avoid unnecessary and expensive differential testing

Treatment

Condition-dependent: Treatment of underlying systemic disease is often the only treatment

Pseudotumor cerebri and other causes of intracranial hypertension: Weight loss, Diamox or Lasix, planned recumbency, LP shunt or optic nerve sheath fenestration if loss of visual function

Space-occupying lesion or hemorrhage: Neurosurgical intervention

Meningoencephalitis: IV antibiotics

Infectious optic neuropathy: Treat underlying cause and consider systemic steroids (controversial)

Optic neuritis: IV (not oral) steroids

Optic nerve glioma treatment controversial: Observation if slowly progressive, resection if only one nerve involved, radiation if chiasm involved, shunts if increased ICP

Toxic or nutritional: Stop offending toxin or supply nutritional supplementation

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What does Christmas music do to your brain?

December 26th, 2009 · Uncategorized

If you love Christmas music (like I do!) then Christmas music probably makes your brain light up and makes your face smile, your feet dance and your endorphins flow.  Why?  Because any music that we have positive associations with, that brings back positive memories or that energizes us, is clearly having a positive effect on the brain:

To that I would add, music that has lots of high, percussive sounds such as tambourines, small bells and brass instruments moving with a fast harmonic rhythm are also apt to stimulate the brain in a positive, energizing, endorphin-producing way!

I hope that you’ve heard lots of your favorite Christmas music this season!  Happy Holidays!  Alice

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Brain can "close eyes" to listen to music

November 11th, 2009 · Uncategorized

 

Brain ‘closes eyes’ to hear music

Our brains can turn down our ability to see to help them listen even harder to music and complex sounds, say experts.
A US study of 20 non-musicians and 20 musical conductors found both groups diverted brain activity away from visual areas during listening tasks.

Scans showed activity fell in these areas as it rose in auditory ones.

But during harder tasks the changes were less marked for conductors than for non-musicians, researchers told a Society for Neuroscience conference.

“ Imagine the difference between listening to someone talk in a quiet room, and that same discussion in a noisy room – you don’t see as much of what’s going on in the noisy room ”
Dr Jonathan Burdette
Wake Forest University Baptist Medical Center
The researchers, from Wake Forest University Baptist Medical Center and the University of North Carolina, used functional Magnetic Resonance Imaging, which can measure real-time changes in brain activity based on the blood flow to different areas of the brain.

Previous research has identified various parts of the brain involved in vision and hearing.

The experiment involved 20 professional orchestral conductors or band leaders and 20 musically untrained students, all aged between 28 and 40.

While lying in the scanner, they were asked to listen to two different musical tones played a few thousandths of a second apart and identify which was played first.

The task was made harder for the professional musicians than for the non-musicians, to allow for the differences in their background.

What the scientists found was that while activity rose, as expected, in the auditory part of the brain, it correspondingly fell in the visual part.

As the task was made harder and harder, the non-musicians carried on diverting more and more activity away from the visual parts of the brain to the auditory side, as they struggled to concentrate.

However, after a certain point, the conductors did not suppress their brains, suggesting that their years of training had provided a distinct advantage in the way their brains were organised.

Finely-tuned brains

Dr Jonathan Burdette, who led the study, said: “This is like closing your eyes to listen to music.

“Imagine the difference between listening to someone talk in a quiet room and that same discussion in a noisy room – you don’t see as much of what’s going on in the noisy room.”

Another researcher, Dr David Hairston, said that the study showed just how flexible this ability was.

“How this operates can change with highly specialised training and experience,” he said.

Dr Bahador Bahrami, from the UCL Institute of Cognitive Neuroscience, said the study showed the difference in “brain organisation” between musicians and non-musicians.

“It demonstrates the mechanisms developed in the brain in the face of distraction. The brains of the conductors are highly tuned to tones.”

Story from BBC NEWS:

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The Music Cortex: How it works

September 23rd, 2009 · music and the brain

Have you heard of the music cortex?  The more we know about how music affects the brain, the more we can incorporate music into our wellness and healing practices.  What could be more fascinating?  The following article is a first-person account of music and the brain from a wonderful blog, https://slipsofthetongue.wordpress.com/2009/09/18/the-music-cortex/Enjoy!

The Music Cortex

Mr. Apron and I sat down at the kitchen table last night to enjoy our dinner of Exploding Pizza, the kind of crust that comes in a tube, and when you peel back the paper it kind of pops, and therefore contains a warning to point it away from your face. We call that Exploding Pizza. On the table was a brochure for Piffaro, a musical ensemble which performs renaissance and baroque music using period instruments, such as recorders, harps, shawms, and, my personal favorite, sackbuts. As I glanced at the various performance descriptions for 17th century Spanish music, I spied a familiar name in the November performance – the husband of a woman led my Early Music Ensemble in college. He came in a few times to support those of us brave enough to take on the shawms and dulcians, which are sort of proto-oboes and proto-bassoons, respectively. We obviously had to go.

“I love taking you to these performances, buddy,” said Mr. Apron as he made a mental note to take me to these performances, “but I hate that it always makes you so sad.”

My brain surgery left my body in less than optimal condition immediately after the surgery. While I’ve pretty much healed up in as much as spontaneous recovery and physical/occupation/speech therapy can do, there are subtle, sub-clinical deficits I still retain. When in the medical model, one refers to body function, whether it’s strength, range of motion, or activities you can do, in varying degrees of impairment, such as mildly, moderately, or severely impaired. In my case, I probably fit the description of WFL, three marvelous letters which stand for Within Functional Limits. This says, essentially, “This person or his body part is suited for all normal functions.” Not quite as gratifying as WNL, Within Normal Limits, WFL simply allows the medical professional to give a cursory assessment and determine that nothing significant is standing in the way of ADLs, (Activities of Daily Living): those happy life skills like dressing oneself; loading the dishwasher; using a spork; and running for/signaling at the SEPTA bus leaving the curb.

I am WFL. My body parts all work WFL. My once-paralyzed left arm, hand, and all five fingers are WFL. I can buckle my seat belt, cut up food with a knife, fasten a necklace, and open a door. My lips/mouth/tongue are WFL. I can chew food, move it around my mouth, form it into a swallow-able glob, and swallow it. I can find pesky pieces of lunch hidden in my cheeks, and I can use a napkin to locate detritus on my lower lip. I am WFL.

If you probe deeper, maybe compare pre- and post-surgery, you’ll see deficits. Maybe not in everyday function, but in measurable impairments. I have very little feeling in my lower lip, chin, and lower cheek on the left half of my face. My left fingertips perceive touch and temperature ever so slightly differently than those on my right hand. What this means for daily life is that sometimes I do miss a piece of food on my face, or drool if I’m sleeping on my left side (which I wouldn’t feel). My left hand might not be up to carrying a dresser long distances. All these differences would not matter for regular old ADLs, but they do matter for a musician.

Immediately after my surgery, my father, a psychiatrist who should have a good handle on brain function, approached my neurosurgeon with some concern regarding my “musical” ability. Now, in this century we’ve moved away from phrenology and believing concretely that lumps on the head/brain correspond to characteristics, strengths, and abilities, but there is emerging research into localization of some functions in the brain, made possible with fMRI, imaging which lights up in brighter colors which portions of the brain are active during certain tasks. I read an article once where the brain surgeons had to do surgery on a professional violinist while she was awake to make sure they had localized and avoided disturbing the “music center” while they operated. They stimulated portions of her brain and then asked her to play the violin to map out her brain during surgery. So my father, with his concerns about my “music center” was not completely out in left field. In fact, there’s a study at Harvard University which has discovered that certain parts of the auditory cortex are sensitive to aspects of music.

In the hospital I could do very little. I couldn’t sit up for any length of time without getting very dizzy and causing my already massive headache to throb even more. Finally, towards the end of the week I spent as an inpatient, I felt well enough to sit up. I tried to spend most of my days sitting up to prove to the nursing staff how much my constitution was improving so they’d let me go home.

My mother plays harp professionally. She plays a lot of weddings and church-related events such as midnight masses and Christmas concerts. She has also played for Mothers Day teas at yacht clubs, a Memorial Day event at a cemetery, and concerts for children. In addition to her concert-sized harp, she has a more portable version, which she brought with her to the hospital, to cheer me up, keep us all busy, and entertain the ward with strains of “If I only had a brain”. In an effort to appease my father’s worries, and for want of something to do that didn’t involve vision (I had double vision immediately after surgery which conveniently went away as soon as I made an appointment with an ophthalmologist 8 weeks later), I asked for the harp. Balancing it on the edge of the bed, cradling the harp between my knees, I propped myself up. My useless left arm lay at my side, but I was able to pluck out “Twinkle Twinkle Little Star” with my right.

Behold! They had spared my “music center”! Not only had the post-operative angiogram shown no residual AVM; they had successfully left intact my musical abilities. Or so it seemed. At least my father was relieved.

Unfortunately, I did not have so much success with my other instruments. When I had regained a little function in my left hand (I became strong enough to lift a spice bottle), I tried the clarinet and the bassoon. My embouchure, the shape of the mouth and lips when playing a wind instrument, was weakened not only by months of disuse, but also was significantly affected by my new deficits. I couldn’t keep a seal on the mouthpiece of my clarinet, and spittle flew out of the left side of my mouth. Bassoon was no better. Even as the months wore on, and my strength improved measurably in therapy, I had no more success. Every time I would pick up my bassoon, I would collapse in tears, wailing as I sat in the living room, apologizing repeatedly to the beautiful (some might argue) instrument. My left hand, as “functional” as it was for the physiatrist, was still too weak to even hold the heft of the 7 pound instrument, let alone support the instrument with my palm and move all five fingers in rapid precise movements. Websites will tell you that bassoonists don’t actually have to feel the weight of their instruments because they’re supported by seat straps. While it’s true they’re not lifting 7 pounds constantly, they do have to hold up the top-heavy instrument as it leans ever so slightly to the left.

I can do all of the range of movement exercises with my facial muscles, and my left hand strength is now pretty good for a non-dominant hand, but it is nowhere near agile enough to play a musical instrument. The rapid movements, the precision, the muscle memory needed for arpeggios, for reaching all of the 17 keys on a bassoon, for sealing the holes of the instrument…I just don’t have those abilities.

When we go to a concert, be it classical music, early music, Indonesian music, or any other genre or instrument I have played, I get sad. I think of how I used to play, used to be in ensembles and have concerts, and go out for Dairy Queen afterwards. I have been in marching bands of 100 pimply teenagers, chamber orchestras made up of physicians, school bands, wind ensembles, early music ensembles, quartets, and summer orchestras large enough to have 8 bassoonists and 40 flautists. With varying degrees of proficiency, I have played piano, recorder, harp, bassoon, clarinet, bari sax, dulcian, krumhorn, viola da gamba, cello, and gamelan (Indonesian percussion) instruments.

I wish I could pick an instrument back up. It’s been so long now that I’d have an uphill battle to relearn the instrument as well as reteach my hands how to play. I avoid even trying. I keep my bassoon locked up in the basement, where I don’t have to think about it. When I pluck out notes on a piano to help Mr. Apron learn his music for plays, I keep my left hand in my lap, ashamed to try to use it. It would be so hard now that I don’t even try. That if I did, it would be so difficult I would get frustrated and give up. The sadness also stems from the fact that, if you hadn’t gathered from my list of instruments and ensembles, music was a pretty big part of my life until my surgery. It’s also a pretty significant part of my family’s life.

My mother, as I mentioned, is a harpist. She is also a pianist. My brother dabbled in drums for a while before returning to piano, his first instrument. Last time I checked, he had completed his college majors in physics and music, ripping through sonatas and pop songs at the speed of lightning. My sister, too, started with piano, and branched off into brass, picking up the trumpet, mainly, but also trying out the euphonium. She also plays the shofar annually at my parents’ synagogue’s High Holy Days celebration, blasting the announcement of the holiday from the ram’s horn for all to hear. My father, though never quite reaching proficiency on the piano, stuck with woodwind instruments. He started with clarinet, as did I, and then moved to bassoon, as did I. I followed his path, waiting for my hands to grow even a smidge more so I could play the bassoon like my father. My first ensemble was a duet with my father. He had put down his clarinet since probably junior high, but dug it out of my grandmother’s closet to play when I started playing in 5th grade. And when I picked up the bassoon, he dusted his off from where it had lain, dormant under the piano, since I was born.

Though the years I’ve had many “clarinet buddies,” playing duets with me, or starting impromptu ensembles. We helped each other improve, and I may have actually done more practicing when playing with a friend. As I moved into high school, I found clarinet buddies in marching band or other low woodwind players in orchestra to be my bassoon buddies (I was always the lone bassoonist). In college, I never quite found any bassoon or clarinet buddies. I couldn’t figure out how to socialize during the breaks at orchestra rehearsal. I was just a shy freshman, the 3rd bassoonist in a section meant for 2. It didn’t seem like much of a loss when I quit orchestra, and, subsequently, bassoon lessons. I hadn’t been motivated to improve in a long time. Away at college, I missed the camaraderie of having music buddies. I didn’t have the motivation to play, or any of the benefits that had always come with music for me.

As Mr. Apron and discussed music last night, I started tearing up. I guess he thought I was again regretting that I have put down my instruments and am afraid to try again. It was all this talk about clarinet buddies. I was realizing that neither Hannah, nor Nadia, nor Jamie, nor Alison, nor Sandy were my first clarinet buddy. My father, who himself had put down his instruments when I was born, was my first clarinet buddy. Though we had built a pink dollhouse together for my 3rd birthday, and gone skiing together when I was 6, the most consistent and longest lasting activity we have shared is music. Music did not care if there was 24” of powder on the ski slope. Music did not care if we had wrist-guards while rollerblading. Music did not leave sawdust in our eyes or require Mickey Mouse ear protectors. Music is something my father supported me in for many years. I understand his fear of my losing my music because of my surgery. He hadn’t realized then that my deficits would not be in the region of the brain that is sensitive to rhythm, melody and harmony, but in my fingers and my discouragement.

We will go to that early music concert in November, and I know I’ll get sad. I’ll also enjoy seeing and hearing the beautiful instruments that I used to hold and play. I’m not sure where I’ll go with music, or if I’ll even persist with an instrument long enough to find out if it’s even possible to play again. I’m still fortunate to have grown up playing and listening to the tunes of my family, in the house where we referred to the living room as “the music room.” The music room was where I danced at age 4 to my mother’s harp practicing, where I set up a crude drum set for my brother made out of oatmeal drums and pie tins, and where my father and I played many hours of duets together.

More than physical impairments, and all the excuses I let my body and brain make for my failure to try again, is motivation. Maybe again I’ll find motivation in one of these concerts – an open call for a mediocre bassoonist, an invitation to come try out the bass recorder, a song I can’t let go of – or in another source. Maybe Mr. Apron will find a duet for banjo and something-I-used-to-play. Maybe I’ll meet someone who inspires me and wants to have jam sessions.

Or maybe we’ll have to grow me another clarinet buddy.

September 18, 2009 in Brain Surgery Tags: AVM, Brain Surgery, music, music cortex, phrenology, Piffaro, the father

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Improve your vocabulary with music!

September 7th, 2009 · Uncategorized

In 1982, researchers from the University of North Texas performed a three-way test on postgraduate students to see if music could help in memorizing vocabulary words. The students were divided into three groups. Each group was given three tests – a pretest, a posttest, and a test a week after the first two tests. All of the tests were identical. Group 1 was read the words with Handel’s Water Music in the background. They were also asked to imagine the words. Group 2 was read the same words also with Handel’s Water Music in the background. Group 2 was not asked to imagine the words. Group 3 was only read the words, was not given any background music, and was also not asked to imagine the words. The results from the first two tests showed that groups 1 and 2 had much better scores than group 3. The results from the third test, a week later, showed that group 1 performed much better than groups 2 or 3. However, simply using music while learning does not absolutely guarantee recall but can possibly improve it. Background music in itself is not a part of the learning process, but it does enter into memory along with the information learned. Recall is better when the same music used for learning is used during recall. Also, tempo appears to be a key of music’s effect on memory.

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